RT Journal Article
SR Electronic
T1 Impact of c-erb2 status on survival after high dose chemotherapy in high-risk breast cancer patients
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1374
OP 1379
VO 28
IS 9
A1 Kuzhan, Okan
A1 Ozet, Ahmet
A1 Ulutin, Cuneyt
A1 Kurt, Bulent
A1 Komurcu, Seref
A1 Ozturk, Bekir
A1 Ataergin, Selmin
A1 Gunhan, Omer
YR 2007
UL http://smj.org.sa/content/28/9/1374.abstract
AB OBJECTIVE: To investigate the impact of c-erb2 status on survival after high-dose chemotherapy.METHODS: Between March 1997 and June 2004, a total of 54 women with breast cancer who has at least 8 metastatic lymph nodes underwent high-dose chemotherapy with hematopoietic stem cell transplantation in Gulhane Military Medical School, Ankara, Turkey. Archival specimens were analyzed by fluorescent in situ hybridization to determine the impact of c-erb2 status after peripheral blood stem cell transplantation on survival. The patients were divided into c-erb2 negative (n=20) and positive (n=11) groups.RESULTS: No statistically significant differences were detected between c-erb2 negative and positive groups regarding 5-year disease-free survival (41 and 27%, log rank p=0.11), and overall survival (60 and 45%, p=0.33). Transplant related mortality did not differ between groups.CONCLUSION: We found no differences between c-erb2 negative and positive groups regarding disease-free and overall survival. To clarify the value of the c-erb2 status in predicting outcome after high-dose chemotherapy, prospective randomized studies are needed.