PT  - JOURNAL ARTICLE
AU  - Wei  Song
AU  - Mingzhen  Yuan
AU  - Shengtian  Zhao
TI  - Variation of M3 muscarinic receptor expression in different prostate tissues and its significance
DP  - 2009 Aug 01
TA  - Saudi Medical Journal
PG  - 1010--1016
VI  - 30
IP  - 8
4099  - http://smj.org.sa/content/30/8/1010.short
4100  - http://smj.org.sa/content/30/8/1010.full
SO  - Saudi Med J2009 Aug 01; 30
AB  - OBJECTIVE: To detect the expression of the muscarinic receptor (M receptor) in different prostate tissues and analyze the role of its subtype in prostatic oncogenesis.METHODS: Thirty-six cases of normal prostate and benign prostatic hyperplasia, and 8 cases of prostatic tumor, were used in this study from the Shandong University, Shandong, China, between 2003-2006. The protein expressions of M1, M2, and M3 receptors in each group were determined by Western-blotting. The gene expressions of the M3 receptor and vascular endothelial growth factors (VEGF) in each group were determined by reverse transcriptase-polymerase chain reaction.RESULTS: The protein and gene expressions of the M3 receptor in the prostatic carcinoma group were higher than that of benign prostatic hyperplasia group (p=0.0001) and normal prostate group (p=0.0001). The M3 receptor and VEGF showed positive straight-line correlations of gene expressions with the 3 groups (r=0.4999, p=0.0001).CONCLUSION: The M3 receptor may have a close relationship with prostatic oncogenesis.