RT Journal Article
SR Electronic
T1 Variation of M3 muscarinic receptor expression in different prostate tissues and its significance
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1010
OP 1016
VO 30
IS 8
A1 Song, Wei
A1 Yuan, Mingzhen
A1 Zhao, Shengtian
YR 2009
UL http://smj.org.sa/content/30/8/1010.abstract
AB OBJECTIVE: To detect the expression of the muscarinic receptor (M receptor) in different prostate tissues and analyze the role of its subtype in prostatic oncogenesis.METHODS: Thirty-six cases of normal prostate and benign prostatic hyperplasia, and 8 cases of prostatic tumor, were used in this study from the Shandong University, Shandong, China, between 2003-2006. The protein expressions of M1, M2, and M3 receptors in each group were determined by Western-blotting. The gene expressions of the M3 receptor and vascular endothelial growth factors (VEGF) in each group were determined by reverse transcriptase-polymerase chain reaction.RESULTS: The protein and gene expressions of the M3 receptor in the prostatic carcinoma group were higher than that of benign prostatic hyperplasia group (p=0.0001) and normal prostate group (p=0.0001). The M3 receptor and VEGF showed positive straight-line correlations of gene expressions with the 3 groups (r=0.4999, p=0.0001).CONCLUSION: The M3 receptor may have a close relationship with prostatic oncogenesis.