RT Journal Article
SR Electronic
T1 Dexamethasone in unexplained infertility
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1034
OP 1036
VO 30
IS 8
A1 Moradan, Sanam
A1 Ghorbani, Raheb
YR 2009
UL http://smj.org.sa/content/30/8/1034.abstract
AB OBJECTIVE: To determine if dexamethasone could be a suitable option in the treatment of patients with unexplained infertility.METHODS: This study was carried out in the Obstetrics Department of Amir University Hospital, Semnan, Iran, from April 2001 to May 2008. One hundred and twenty-four cases of unexplained infertility that underwent ovulation induction and intrauterine insemination (IUI) (only one cycle) were evaluated, and divided into 2 groups. Sixteen cases were excluded, as they were unresponsive to the induction ovulation regimen. Group I (n=42) received clomiphene citrate (CC) + dexamethasone, and the control group (group II, n=66) received CC alone. These groups were the same in age, duration of infertility, and body mass index. The clinical pregnancy rates were evaluated in 2 groups by using statistical tests.RESULTS: The clinical pregnancy rate was 21.4% in group I, and 4.5% in group II. There was a significant statistical difference between the groups (relative risk=4.71, 95% confidence interval=1.35-16.42, p=0.0085).CONCLUSION: The pregnancy rate in women with unexplained infertility that underwent ovulation induction with CC + dexamethasone + IUI was significantly higher than those who underwent ovulation induction with CC alone + IUI.