RT Journal Article SR Electronic T1 A loxoscelism case received therapeutic apheresis and hyperbaric oxygen therapy JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1364 OP 1368 DO 10.15537/smj.2020.12.25544 VO 41 IS 12 A1 Ali Cetinkaya A1 Kaniye Aydin A1 Hatice A. Sirakaya A1 Rumeysa Yilmaz YR 2020 UL http://smj.org.sa/content/41/12/1364.abstract AB Loxosceles reclusa (L.reclusa) is known to bite humans, and its venom includes several enzymes that cause clinical symptoms. Loxoscelism, a condition due to being bitten by Loxosceles spiders, commonly known as recluses, can involve a range of clinical conditions, from local cutaneous lesions to severe systemic involvement. The diagnosis of loxoscelism is usually made by anamnesis and clinical findings. Magnetic resonance imaging is recommended for patients at high risk of necrotizing fasciitis. Treatment modalities are still controversial and there is no standardized treatment approach. Reported here, our case of loxoscelism involved a 24-year-old man presenting with a Loxosceles spider bite, dermonecrotic lesion, vomiting, diarrhea, acute renal injury, and rhabdomyolysis, who was successfully treated with hyperbaric oxygen therapy, therapeutic apheresis, hemodialysis, wound debridement, and cutaneous autografting. Early diagnosis and multidisciplinary approach can be life-saving in spider bites that can cause systemic involvement. Loxoscelism should be considered in patients with skin necrosis, acute renal injury, and rhabdomyolysis.