RT Journal Article
SR Electronic
T1 Association between preeclampsia and prostasin polymorphism in Pakistani females
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1234
OP 1240
DO 10.15537/smj.2020.11.25497
VO 41
IS 11
A1 Ejaz, Saima
A1 Ali, Anwar
A1 Azim, Kamran
A1 Mahmood, Atif
A1 Khan, Asif I.
A1 Almazyad, Tuline A.
A1 Bilal, Bushra
YR 2020
UL http://smj.org.sa/content/41/11/1234.abstract
AB Objectives: To investigate the relationship between a prostasin gene variations and the development of preeclampsia in a Pakistani female population.Methods: This was a case-control study carried out at University of Karachi, Karachi, Pakistan between May 2018 and 2019. A single nucleotide polymorphism (SNP) at rs12597511 locus was examined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analyses in 76 preeclamptic and 74 normotensive expecting mothers.Results: We observed significantly increased risk of preeclampsia associated with the CC genotype of rs12597511 polymorphism as compared to TT (p<0.001, OR=8.08, 95% CI:1.28-31.19) and TT/TC (p<0.001, OR=14.66 and 95% CI: 3.31-65.07) genotypes carriers. Calculation of the allelic distribution revealed a higher frequency of the T allele (82%) among controls; however, the C allele was more prevalent in the preeclamptic group (36%) significantly.Conclusion: The significantly higher C allele frequency in the prostasin gene at the rs12597511 locus in the preeclamptic group indicates that the distribution of the C allele of the prostasin gene is a potential risk factor contributing to the development of preeclampsia.