PT - JOURNAL ARTICLE AU - Al-Mshari, Arwa Ali S. AU - AlSheikh, Mona H. AU - Latif, Rabia AU - Mumtaz, Sadaf TI - The effect of smoking on cognition as measured by Cambridge Neuropsychological Test Automated Battery (CATNAB) and brain-derived neurotrophic factor plasma levels AID - 10.15537/smj.2020.12.25513 DP - 2020 Dec 01 TA - Saudi Medical Journal PG - 1308--1314 VI - 41 IP - 12 4099 - http://smj.org.sa/content/41/12/1308.short 4100 - http://smj.org.sa/content/41/12/1308.full SO - Saudi Med J2020 Dec 01; 41 AB - Objectives: To establish an association between cigarette smoking, cognition, and plasma brain-derived neurotrophic factor (BDNF) levels in healthy young adults.Methods: This was an ex post facto analytic cross-sectional study conducted between March and November 2018. Participants were 73 healthy males (31 smokers and 42 non-smokers), 17-33 years old. The cognitive function of the participants was assessed through the Cambridge neuropsychological test automated battery (CANTAB). Blood samples were taken to measure the plasma levels of BDNF and the results were compared to identify the association between smoking related variables and cognitive test scores and plasma BDNF levels. A p-value of <0.05 was considered statistically significant.Results: Smokers performed significantly worse than non-smokers in the multitasking test, including reaction time and rapid visual information processing. However, no significant association was observed between smoking related variables and cognitive test scores. The only significant positive correlation was found between plasma BDNF levels and the number of cigarettes smoked per day (r=0.480, p=0.024). No correlation was observed between other smoking related variables and plasma BDNF levels.Conclusion: Plasma BDNF level is positively related to the number of cigarettes smoked per day. Young smokers have significantly impaired sustained attention and less ability to manage conflicting information as compared to age-matched non-smokers.