RT Journal Article
SR Electronic
T1 The prevalence, clinical features, predictive factors and investigations to screen for cancer in patients with inflammatory myositis
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 100
OP 104
DO 10.15537/smj.2021.1.25590
VO 42
IS 1
A1 Ghassan Aljohani
A1 Eman A. Bin Awad
A1 Khalid Alshahrani
A1 Mubark M. Alsaqar
A1 Bashayer Albogami
A1 Saleh H. Almotywee
A1 Hisham Almaimouni
A1 Abdullah S. Dirar
A1 Abdulrahman Alrashid
A1 Rajkumar Rajendram
A1 Emad Masuadi
A1 Mohammed A. Omair
YR 2021
UL http://smj.org.sa/content/42/1/100.abstract
AB Objectives: To describes the epidemiology of cancer in patients with idiopathic inflammatory myopathies (IIM) treated at 2 tertiary centers in Riyadh, Saudi Arabia.Methods: This was a retrospective multi-center study evaluating the prevalence and the type of malignancy in an IIM population in King Saud University Medical City and King Abdulaziz Medical City between August 2017 to August 2018.Results: In total, 60 patients were included. Four had neoplasms (6.7%), 2 men had lymphoma, a woman had breast cancer and a second, ovarian cancer. Two patients died due to cancer or its complications. Older age (age >40 years), dysphagia, necrotic rash, absence of interstitial lung disease, high erythrocyte sedimentation rate and a negative anti Jo-1 antibody were potentially predictive risk factors for neoplasm. All patients diagnosed with cancer-associated myositis were investigated with routine and invasive modalities. Three of the 4 patients had abnormal findings in both modalities. One patient, the routine investigations were unremarkable, but a computed tomography of the pelvis revealed an ovarian mass that was subsequently diagnosed as malignant.Conclusion: An individualized approach might be more appropriate for high risk patients. Larger prospective studies are required to confirm the findings of the current study.