RT Journal Article SR Electronic T1 Efficacy of gluten- and casein-free diets on autism spectrum disorders in children JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1041 OP 1046 DO 10.15537/smj.2020.10.25308 VO 41 IS 10 A1 Eman S. Alamri YR 2020 UL http://smj.org.sa/content/41/10/1041.abstract AB Food containing gluten and casein could play a role in autism spectrum disorders (ASD) symptoms. The present review aimed to update the evidence about the role of the gluten- and casein-free diet (GCFD) on the management of ASD. Web of Science, Science Direct, Google Scholar, and PubMed databases were used to search for randomized controlled trials (RCT) conducted between January 2000 and February 2020. In total, 9 RCT were included (521 participants) with age range between 2 to 18 years. Four of these studies did not show a significant improvement regarding the symptoms of ASD. The rest of these studies (n=5) showed improvement in communication, stereotyped movements, aggressiveness, language, hyperactivity, tantrums, and signs of attention deficit hyperactivity disorder compared to control group. Hence, the data remains insufficient to support the use of GCFD to improve the symptoms of ASD in children.