RT Journal Article
SR Electronic
T1 Nasopharyngeal carcinoma metastasis to the breast
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1130
OP 1134
DO 10.15537/smj.2020.10.25420
VO 41
IS 10
A1 Abdulkader M. Albasri
YR 2020
UL http://smj.org.sa/content/41/10/1130.abstract
AB Breast metastases from extra-mammary neoplasms are rare, accounting for <2% of breast cancer cases. A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate, eosinophilic to amphophilic cytoplasm and enlarged, hyperchromatic and pleomorphic nuclei with irregular nuclear membranes. An immunohistochemistry (IHC) examination was positive for pan cytokeratin and negative for CK7, CK20, S-100, LCA, HMB45, CD 20, desmin, myogenin, GCFDP-15, transcription factor-1, villin, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. As she was a known case of nasopharyngeal carcinoma, and based on the histopathology findings and IHC profile, the patient was diagnosed with breast metastasis from NPC. The patient was deceased 3 months after refusing the recommended medical intervention.