RT Journal Article
SR Electronic
T1 Risk factors for transposition of the great arteries in Saudi population
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1054
OP 1062
DO 10.15537/smj.2020.10.25418
VO 41
IS 10
A1 Alfarhan, Abdulrahman
A1 Alquayt, Meshari
A1 Alshalhoub, Mohammed
A1 Alnahdi, Muhannad A.
A1 Masuadi, Emad
A1 Alhabshan, Fahad
YR 2020
UL http://smj.org.sa/content/41/10/1054.abstract
AB Objectives: To assess potential risk factors and their effect on the development of transposition of the great arteries (TGA).Methods: A retrospective case-control study of all patients diagnosed with TGA between 1999 to 2016 at King Abdulaziz Medical City, Riyadh, Saudi Arabia. Age and gender-matched controls were selected. Risk factors, including consanguinity, gestational diabetes, family history of congenital heart disease, parental age, and maternal parity, were collected. Regression modeling was used to analyze the effects of risk factors on the development of TGA.Results: A total of 206 patients with transposition of the great arteries were enrolled in the study. Transposition of the great arteries cases were divided into simple and complex TGA. Selected healthy controls were 446. In the studied cases, consanguinity was found in 95 (46%) of cases, gestational diabetes was diagnosed in 36 (17.5%) mothers, and 35 (17%) had a confirmed family history of congenital heart disease. When risk factors of the cases were compared to the controls, consanguinity, gestational diabetes, maternal age, and parity were found to significantly increase the incidence of TGA.Conclusion: Our study revealed significant risk factors for the development of transposition of great arteries including first degree consanguineous marriages, gestational diabetes, family history of congenital cardiac anomalies, and increasing maternal age and parity. These factors increased the risk by at least 2 folds.