RT Journal Article
SR Electronic
T1 Acinar cell ultrastructure after taurine treatment in rat acute necrotizing pancreatitis
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 446
OP 452
VO 27
IS 4
A1 Ates, Yuksel
A1 Mas, Mehmet R.
A1 Mas, Nuket
A1 Tasci, Ilker
A1 Comert, Bilgin
A1 Isik, Ahmet T.
A1 Yener, Nuran
YR 2006
UL http://smj.org.sa/content/27/4/446.abstract
AB OBJECTIVE: To evaluate the organelle-based changes in acinar cells in experimental acute necrotizing pancreatitis (ANP) after taurine treatment and the association of electron microscopic findings with histopathological changes and oxidative stress markers.METHODS: The study was performed in February 2005 at Gulhane School of Medicine and Hecettepe University, Turkey. Forty-five rats were divided into 3 groups. Acute necrotizing pancreatitis was induced in groups II and III. Groups I and II were treated with saline and Group III with taurine 1000 mg/kg/day, i.p, for 48 hours. Histopathological and ultrastructural examinations were determined using one-way analysis of variance and Kruskal-Wallis tests.RESULTS: Histopathologic findings improved significantly after taurine treatment. Degree of injury in rough and smooth endoplasmic reticulums, Golgi apparatus, mitochondria and nucleus of acinar cells also decreased with taurine in correlation with biochemical and histological results.CONCLUSION: Taurine improves acinar cell organelle structure, and ultrastructural recovery in ANP reflects histological improvement.