PT  - JOURNAL ARTICLE
AU  - Mellati, Ali A.
TI  - The role of heat shock proteins as chaperones on several human diseases
DP  - 2006 Sep 01
TA  - Saudi Medical Journal
PG  - 1302--1305
VI  - 27
IP  - 9
4099  - http://smj.org.sa/content/27/9/1302.short
4100  - http://smj.org.sa/content/27/9/1302.full
SO  - Saudi Med J2006 Sep 01; 27
AB  - Some heat shock proteins HSPs, act as molecular chaperones. These and other molecular chaperones that are not HSPs, function in a variety of protein biosynthetic event and protect proteins from the deleterious effects of stressors by stabilizing, and refolding proteins. They assist protein folding, assembly, transport and degradation. Several human diseases such as neurodegeneration, cancer, aging, retinal dystrophy, and inflammation arise from defects HSPs and protein folding. This review demonstrates the chaperones such as properties of HSPs in cellular processes and their implication in different kind of human diseases.