RT Journal Article
SR Electronic
T1 Early colonization of intestinal bifidobacteria and lactobacilli in the postoperative neonates with congenital intestinal atresia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 265
OP 270
VO 32
IS 3
A1 Wang, Ren
A1 Chen, Jinjin
YR 2011
UL http://smj.org.sa/content/32/3/265.abstract
AB OBJECTIVE: To observe the early colonization of bifidobacteria and lactobacilli (B&L) in the postoperative neonate patients (NPs) with congenital intestinal atresia (CIA).METHODS: A prospective study was conducted in Shanghai Children's Hospital, Shanghai, China between February 2009 to August 2010 on 18 postoperative NPs with CIA (NP group), and 20 healthy full-term neonates raised by breastfeeding (healthy group). The fecal B&L in the 2 groups of neonates were consecutively quantified by real-time fluorescence quantitative polymerase chain reaction on 6 different time points.RESULTS: The mean levels (log/g feces) of B&L in the NPs group were significantly lower than in the healthy group at the end point of study (bifidobacteria: NPs [6.3] versus healthy [9.9]; lactobacilli: NPs [6.9] versus healthy [7.6]). Significant differences between the 2 groups also existed on the colonization time (days) of the intestinal B&L (bifidobacteria: NPs [5.8] versus healthy [3.0]; lactobacilli: NPs [4.2] versus healthy [1.2]). Both groups colonized lactobacilli earlier than bifidobacteria. During the study period, levels of bifidobacteria in the NPs group were continuously decreasing compared to lactobacilli, which was opposite to the healthy group.CONCLUSION: The colonization of the intestinal B&L in the postoperative NPs with CIA was severely interfered. The proliferation of bifidobacterium was more restrained than lactobacillus.