PT  - JOURNAL ARTICLE
AU  - Unal, Yusuf
AU  - Sema, Oncul
AU  - Bekir, Demirel C.
AU  - Demet, Yilmazer
AU  - Mustafa, Arslan
AU  - Mustafa, Kavutcu
AU  - Murat, Alper
AU  - Gizem, Ilvan
TI  - The effect of lidocaine on the endothelium damage in rabbit vein grafts
DP  - 2011 Mar 01
TA  - Saudi Medical Journal
PG  - 236--240
VI  - 32
IP  - 3
4099  - http://smj.org.sa/content/32/3/236.short
4100  - http://smj.org.sa/content/32/3/236.full
SO  - Saudi Med J2011 Mar 01; 32
AB  - OBJECTIVE: To investigate the effects of perivascular and intravenous application of lidocaine on venous endothelial morphology of harvested rabbit vein graft.METHODS: This study was conducted in Gazi University Animal Research Laboratory, Ankara, Turkey in March 2009. Three ear veins of each rabbits (n=6) were used. Control group (Group C, n=6 vessels), vein segment was excised from the distal end. Perivascular group (Group P, n=6); 2 ml lidocaine 1% was injected in the perivascular area of the second vein of the same ear, and the vein segment was excised. Intravascular group (Group I, n=6); the vein in the second ear was clamped and 2 ml of lidocaine 1% was administered intravascular, and 5 minutes later, a 2 cm vein segment was excised. Nitric oxide synthase and thiobarbutiric acid reactive substance levels were measured, and histopathologic examination was performed to assess the effects of lidocaine administration.RESULTS: Histopathological findings in groups C, P and I were similar. There were lower thiobarbituric reactive substances level in groups I (p=0.024) and P (p=0.041) than the control group. Nitric oxide synthase activity was higher in groups I (p=0.026) and P (p=0.037) when compared to group C.CONCLUSION: Our results showed both perivascular infiltration and intravascular administration could prevent the consequences of endothelium damage that occurs during the harvesting of veins.