RT Journal Article
SR Electronic
T1 Prognostic value of late gadolinium enhancement in dilated cardiomyopathy patients. A meta-analysis
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 719
OP 726
VO 34
IS 7
A1 Shi, Hong-Wei
A1 Pu, Peng
A1 Deng, Wei
A1 Zhou, Heng
A1 Bian, Zhou-Yan
A1 Shen, Di-Fei
A1 Xie, Jing
A1 Salerno, Michael
A1 Tang, Qi-Zhu
YR 2013
UL http://smj.org.sa/content/34/7/719.abstract
AB OBJECTIVE: To evaluate the prognostic value of late gadolinium enhancement (LGE) in dilated cardiomyopathy (DCM) patients.METHODS: We searched PubMed, MEDLINE, the Cochrane library and EMBASE databases from September to December 2012 in the Renmin Hospital of Wuhan University, Wuhan, China for studies of LGE in DCM patients. We extracted the clinical outcomes (all-cause mortality, cardiovascular mortality, sudden cardiac death [SCD], aborted SCD, heart failure hospitalization) after carefully reviewed. A meta-analysis was performed to calculate pooled odds ratios (OR) with 95% confidence intervals (CIs) for prognostic outcomes in LGE positive versus LGE negative patients with DCM.RESULTS: Five studies for 545 DCM patients were contained in this meta-analysis. The results showed LGE positive patients was significantly associated with higher cardiovascular mortality (pooled OR: 2.67; 95% CI: 1.12-6.35; p=0.03), aborted SCD (pooled OR: 5.26; 95% CI: 1.57-17.55; p=0.007), and heart failure hospitalization (pooled OR: 3.91; 95% CI: 1.99-7.69; p<0.001).CONCLUSION: Late gadolinium enhancement during cardiac MRI is significantly associated with cardiovascular mortality, aborted SCD and heart failure hospitalization in DCM patients. The LGE can be a potential stratification tool to predict the risk of cardiac events among patients with DCM.