PT  - JOURNAL ARTICLE
AU  - Hasukic, Sefik I.
AU  - Iljazovic, Ermina S.
AU  - Odobasic, Amer H.
AU  - Matovic, Ervin A.
TI  - A rare case of primary rectal adenocarcinoma metastatic to the breast
DP  - 2012 Sep 01
TA  - Saudi Medical Journal
PG  - 1014--1017
VI  - 33
IP  - 9
4099  - http://smj.org.sa/content/33/9/1014.short
4100  - http://smj.org.sa/content/33/9/1014.full
SO  - Saudi Med J2012 Sep 01; 33
AB  - Primary rectal adenocarcinoma metastatic to the breast is an exceedingly rare event. Its management differs from that of primary breast cancer, as illustrated by this case. A 63-year-old woman presented with a breast lump 30 months after abdominoperineal resection for rectal adenocarcinoma, stage T3N1M0 (stage III), followed by standard postoperative radiochemotherapy. The patient underwent a mammography and ultrasonography. A CT scan of the abdomen showed metastatic disease. An excisional biopsy of the breast lump was performed; morphological features were identical to the original rectal cancer. Immunohistochemical results were negative for estrogen and progesterone receptors and gross cystic disease fluid protein-15, and intensity positive for cytokeratin 20 and carcinoembryonic antigen. The patient died after treatment with palliative chemotherapy. Metastatic disease from rectal carcinoma to the breast is a marker for disseminated metastatic spread with poor prognosis.