RT Journal Article
SR Electronic
T1 A rare case of primary rectal adenocarcinoma metastatic to the breast
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1014
OP 1017
VO 33
IS 9
A1 Hasukic, Sefik I.
A1 Iljazovic, Ermina S.
A1 Odobasic, Amer H.
A1 Matovic, Ervin A.
YR 2012
UL http://smj.org.sa/content/33/9/1014.abstract
AB Primary rectal adenocarcinoma metastatic to the breast is an exceedingly rare event. Its management differs from that of primary breast cancer, as illustrated by this case. A 63-year-old woman presented with a breast lump 30 months after abdominoperineal resection for rectal adenocarcinoma, stage T3N1M0 (stage III), followed by standard postoperative radiochemotherapy. The patient underwent a mammography and ultrasonography. A CT scan of the abdomen showed metastatic disease. An excisional biopsy of the breast lump was performed; morphological features were identical to the original rectal cancer. Immunohistochemical results were negative for estrogen and progesterone receptors and gross cystic disease fluid protein-15, and intensity positive for cytokeratin 20 and carcinoembryonic antigen. The patient died after treatment with palliative chemotherapy. Metastatic disease from rectal carcinoma to the breast is a marker for disseminated metastatic spread with poor prognosis.