RT Journal Article
SR Electronic
T1 The impact of human epidermal growth factor receptor-2 status of invasive breast tumors on thermography findings
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1118
OP 1121
VO 33
IS 10
A1 Zvonimir Zore
A1 Ivanka Boras
A1 Irina Filipovic-Zore
A1 Mladen Stanec
A1 Miroslav Lesar
A1 Danko V. Vrdoljak
YR 2012
UL http://smj.org.sa/content/33/10/1118.abstract
AB OBJECTIVE: To analyze the impact of prognostic human epidermal growth factor receptor-2 (HER-2) in invasive breast cancers on the findings of thermography tests.METHODS: The study was carried out at the Department of Surgical Oncology and the Department of Pathology, University Clinical Hospital Center, Sisters of Mercy, Zagreb, Croatia, in collaboration with licensed infrared (IR) thermography experts. The study involved 75 female patients diagnosed with invasive breast cancer from May to July 2011. Thermography findings were compared between different immune-histochemical (IHC) findings (HER-2 status: positive or negative).RESULTS: Significantly higher temperatures were recorded in invasive cancer breasts than in healthy breasts. The cancer sites and the entire cancer breasts were significantly warmer (p less than 0.001) than the healthy breasts and opposite tumors mirror sites. Considering the HER-2 status, HER-2 positive invasive cancers were significantly warmer in comparison with the HER-2 negative cancers (p=0.035).CONCLUSION: The trend of increased temperature in HER-2+ tumors was noted. The findings clearly indicate that HER-2+ status has a higher impact on the increased thermographic temperature findings.