TY - JOUR T1 - Clonidine versus tramadol for post spinal anesthesia shivering JF - Saudi Medical Journal JO - Saudi Med J SP - 363 LP - 369 DO - 10.15537/smj.2021.42.4.20200342 VL - 42 IS - 4 AU - Jinguo Wang AU - Haixiao Zhao AU - Yanhui Li AU - Rui Wang AU - Na Wang Y1 - 2021/04/01 UR - http://smj.org.sa/content/42/4/363.abstract N2 - Objectives: To compare clonidine with tramadol for shivering control following spinal anesthesia.Methods: The literature was searched updated to August 2020, and only randomized controlled trials comparing clonidine and tramadol for shivering control following spinal anesthesia were eligible for this study.Results: Fourteen studies with 960 patients were identified. Clonidine demonstrated a lower effective rate of shivering control (OR: 0.59; 95% CI: 0.40-0.88; p=0.009; I2=36%), but with decreased occurrence of nausea, vomiting, and dizziness. Clonidine increased the occurrence of bradycardia, hypotension, and sedation compared to tramadol.Conclusion: Tramadol is more effective for shivering control than clonidine, but with increased occurrence of nausea, vomiting, and dizziness.PROSPERO No: CRD42020207979 ER -