RT Journal Article SR Electronic T1 Clonidine versus tramadol for post spinal anesthesia shivering JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 363 OP 369 DO 10.15537/smj.2021.42.4.20200342 VO 42 IS 4 A1 Wang, Jinguo A1 Zhao, Haixiao A1 Li, Yanhui A1 Wang, Rui A1 Wang, Na YR 2021 UL http://smj.org.sa/content/42/4/363.abstract AB Objectives: To compare clonidine with tramadol for shivering control following spinal anesthesia.Methods: The literature was searched updated to August 2020, and only randomized controlled trials comparing clonidine and tramadol for shivering control following spinal anesthesia were eligible for this study.Results: Fourteen studies with 960 patients were identified. Clonidine demonstrated a lower effective rate of shivering control (OR: 0.59; 95% CI: 0.40-0.88; p=0.009; I2=36%), but with decreased occurrence of nausea, vomiting, and dizziness. Clonidine increased the occurrence of bradycardia, hypotension, and sedation compared to tramadol.Conclusion: Tramadol is more effective for shivering control than clonidine, but with increased occurrence of nausea, vomiting, and dizziness.PROSPERO No: CRD42020207979