PT  - JOURNAL ARTICLE
AU  - Rabah, Danny
AU  - Al-Taweel, Waleed
AU  - Khan, Farrukh
AU  - Arafa, Mostafa
AU  - Mehmood, Shahbaz
AU  - Mokhtar, Alaa
AU  - Farhat, Karim
TI  - Transperineal versus transrectal multi-parametric magnetic resonance imaging fusion targeted prostate biopsy
AID  - 10.15537/smj.2021.42.6.20200771
DP  - 2021 Jun 01
TA  - Saudi Medical Journal
PG  - 649--654
VI  - 42
IP  - 6
4099  - http://smj.org.sa/content/42/6/649.short
4100  - http://smj.org.sa/content/42/6/649.full
SO  - Saudi Med J2021 Jun 01; 42
AB  - Objectives: To compare transperineal biopsies (TPBx) with transrectal ultrasound-guided biopsy (TRUSBx) in order to provide evidence, making clinicians able to select the appropriate biopsy approach under different conditions.Methods: A comparative prospective study, conducted in King Khalid University Hospital (KKUH) and King Faisal Specialist Hospital and Research Centre (KFSH&RC), Riyadh, Kingdom of Saudi Arabia, between March 2019 and February 2020. All patients with raised prostate-specific antigen or atypical digital rectal examination findings were subjected to multi-parametric magnetic resonance imaging (MRI). Those with positive findings were referred to targeted fusion- guided biopsy either TPBx or TRUSBx, randomly. Complication rate, cancer detection rate, and procedure time were recorded.Results: Transperineal biopsies and TRUSBx had an equivalent complication rate. However, both case detection rate and clinically significant cancer detection rate were significantly higher in TPBx versus TRUSBx (45.1% versus 29.1%, p=0.003; and 71.8% versus 43.7%, p=0.002; respectively). Transperineal biopsies was a longer procedure than TRUSBx (41.2±0.7 min versus 13±2.3 min, p=0.0001).Conclusion: No difference in complication rate was detected between the 2 procedures; however, TPBx was more effective for cancer detection in general and clinically significant cancer detection in particular.