TY - JOUR T1 - Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting JF - Saudi Medical Journal JO - Saudi Med J SP - 707 LP - 713 DO - 10.15537/smj.2021.42.7.20210135 VL - 42 IS - 7 AU - Rui Wang AU - Xuesong Song AU - Yan Chen AU - Na Wang AU - Jinguo Wang Y1 - 2021/07/01 UR - http://smj.org.sa/content/42/7/707.abstract N2 - Objectives: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).Methods: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.Results: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.Conclusions: Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368 ER -