%0 Journal Article %A Rui Wang %A Xuesong Song %A Yan Chen %A Na Wang %A Jinguo Wang %T Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting %B A meta-analysis of randomized controlled trials %D 2021 %R 10.15537/smj.2021.42.7.20210135 %J Saudi Medical Journal %P 707-713 %V 42 %N 7 %X Objectives: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).Methods: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.Results: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.Conclusions: Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368 %U https://smj.org.sa/content/smj/42/7/707.full.pdf