PT  - JOURNAL ARTICLE
AU  - Wang, Rui
AU  - Song, Xuesong
AU  - Chen, Yan
AU  - Wang, Na
AU  - Wang, Jinguo
TI  - Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting
AID  - 10.15537/smj.2021.42.7.20210135
DP  - 2021 Jul 01
TA  - Saudi Medical Journal
PG  - 707--713
VI  - 42
IP  - 7
4099  - http://smj.org.sa/content/42/7/707.short
4100  - http://smj.org.sa/content/42/7/707.full
SO  - Saudi Med J2021 Jul 01; 42
AB  - Objectives: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).Methods: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.Results: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.Conclusions: Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368