RT Journal Article
SR Electronic
T1 Comparison of ondansetron and tropisetron in preventing postoperative nausea and vomiting
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 707
OP 713
DO 10.15537/smj.2021.42.7.20210135
VO 42
IS 7
A1 Wang, Rui
A1 Song, Xuesong
A1 Chen, Yan
A1 Wang, Na
A1 Wang, Jinguo
YR 2021
UL http://smj.org.sa/content/42/7/707.abstract
AB Objectives: To compare the efficacy of prophylactic ondansetron and tropisetron for postoperative nausea and vomiting (PONV).Methods: A literature search was performed to identify studies that compare the efficiency of ondansetron with that of tropisetron in preventing PONV. Only randomized controlled trials updated to January, 2021 were included.Results: The final pooled analysis included 14 studies totaling 1705 patients and indicated that ondansetron was 39% less effective than tropisetron in preventing postoperative vomiting with a higher incidence of dizziness. However, no significant difference was detected between ondansetron and tropisetron in PONV, postoperative nausea, antiemetic treatment, and headache.Conclusions: Tropisetron is superior to ondansetron in preventing postoperative vomiting.PROSPERO No: CRD42021237368