RT Journal Article
SR Electronic
T1 Association between sex hormones and migraine in young Saudi females
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 793
OP 797
DO 10.15537/smj.2021.42.7.20210110
VO 42
IS 7
A1 Al Asoom, Lubna I.
A1 Alajmi, Modhi S.
A1 Alsudairi, Reem R.
A1 AlShamlan, Abeer A.
A1 Almomaten, Amal A.
A1 Alqarni, Asma A.
A1 Alshammari, Manal H.
A1 Rafique, Nazish
A1 Latif, Rabia
A1 Alsunni, Ahmed A.
A1 Almohazey, Dana A.
A1 Alsuwat, Hind S.
A1 Azeez, Sayed Abdul
A1 Borgio, Francis J.
YR 2021
UL http://smj.org.sa/content/42/7/793.abstract
AB Objectives: To assess the sex hormone levels in young Saudi female migraineurs during a migraine attack and during pain-free periods and compare them with control subjects.Methods: A case-control study involving 14 Saudi female migraineurs and 21 control subjects was conducted between December 2019 and March 2020. Demographic and disease history data were collected through participant interviews. Blood samples were drawn during the migraine attack and pain-free periods.Results: Follicular (30.00±19.60; p<0.001) and luteal (39.79±11.45; p=0.037) estrogen levels were significantly higher in patients with non-menstrual related migraine (NMM), while luteal testosterone levels (1.10±0.31; p=0.023) were significantly higher in patients with menstrually related migraine (MM). Body mass index (BMI) was higher in patients with NMM (25.77±6.53; p=0.013), and it was found to be associated with follicular estrogen (p=0.016), progesterone (p=0.018), and pain intensity (p=0.042). Luteal estrogen level was significantly lower (13.96±7.88; p=0.036) in patients with luteal onset of attack.Conclusion: High estrogen levels were found to mediate NMM, their effect being more pronounced with increase in BMI; whereas low luteal estrogen levels mediated MM. Young females with MM might have high luteal testosterone levels, and a compensatory protective role could be surmised accordingly.