PT - JOURNAL ARTICLE AU - Mohammed F. Alosaimi AU - Abdulkarim Alhetheel AU - Khalid A. Aleisa AU - Abdullah A. Altwerki AU - Njoud M. Alenezy AU - Ebtisam M. Almutairi AU - Leen O. Alothaim AU - Abdul Manan A. Khalid AU - Khalid M. Alayed AU - Mohammed A. Almazyad AU - Turki A. BinMoammar AU - Fahdah A. Alshobaili AU - Fatimah S. Al-Shahrani AU - Sarah Alsubaie AU - Rana M. Hasanato TI - Risk factors and predictors that influence SARS-Cov-2 IgG positivity AID - 10.15537/smj.2021.42.8.20210238 DP - 2021 Aug 01 TA - Saudi Medical Journal PG - 853--861 VI - 42 IP - 8 4099 - http://smj.org.sa/content/42/8/853.short 4100 - http://smj.org.sa/content/42/8/853.full SO - Saudi Med J2021 Aug 01; 42 AB - Objectives: To study the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after pandemic’s peak and before the vaccine enrollment in Riyadh, Saudi Arabia and further explore predictors for SARS-CoV-2 positivity.Methods: A cross-sectional study of 515 blood donors from November 22 to December 17, 2020 was conducted at King Saud University Medical City, Riyadh, Saudi Arabia to look at SARS-CoV-2 immunoglobulin G (IgG) positivity. The participants were asked questions about their demographic characteristics, past SARS-CoV-2 infection, SARS-CoV-2-related symptoms and exposures.Results: The seroprevalence in our study was 12.2% (n=63/515). Being a non-citizen was associated with significantly higher seroprevalence (OR 2.10, p=0.02). Participants with history of SARS-CoV-2 exposure or symptoms regardless of SARS-CoV-2 diagnosis had higher SARS-CoV-2 IgG positivity compared to unexposed or asymptomatic participants (OR 2.47, p=0.0008 or 11.19, p=0.0001, respectively). Blood donors who had symptomatic SARS-CoV-2 IgG infection had a higher SARS-CoV-2 IgG positivity rate (OR 5.04, p=0.008) and index value (p=0.003) than the asymptomatic. Of all the reported symptoms, cough (p=0.004) and anosmia (p=0.002) were significant predictors of SARS-CoV-2 IgG.Conclusion: The seroprevalence of SARS-CoV-2 among the blood donors in Riyadh, Saudi Arabia is considerably lower than the percentages necessary for herd immunity. Developing SARS-CoV-2-symptoms is the critical factor for higher seropositivity after SARS-CoV-2 exposure.