RT Journal Article
SR Electronic
T1 Risk factors and predictors that influence SARS-Cov-2 IgG positivity
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 853
OP 861
DO 10.15537/smj.2021.42.8.20210238
VO 42
IS 8
A1 Alosaimi, Mohammed F.
A1 Alhetheel, Abdulkarim
A1 Aleisa, Khalid A.
A1 Altwerki, Abdullah A.
A1 Alenezy, Njoud M.
A1 Almutairi, Ebtisam M.
A1 Alothaim, Leen O.
A1 Khalid, Abdul Manan A.
A1 Alayed, Khalid M.
A1 Almazyad, Mohammed A.
A1 BinMoammar, Turki A.
A1 Alshobaili, Fahdah A.
A1 Al-Shahrani, Fatimah S.
A1 Alsubaie, Sarah
A1 Hasanato, Rana M.
YR 2021
UL http://smj.org.sa/content/42/8/853.abstract
AB Objectives: To study the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after pandemic’s peak and before the vaccine enrollment in Riyadh, Saudi Arabia and further explore predictors for SARS-CoV-2 positivity.Methods: A cross-sectional study of 515 blood donors from November 22 to December 17, 2020 was conducted at King Saud University Medical City, Riyadh, Saudi Arabia to look at SARS-CoV-2 immunoglobulin G (IgG) positivity. The participants were asked questions about their demographic characteristics, past SARS-CoV-2 infection, SARS-CoV-2-related symptoms and exposures.Results: The seroprevalence in our study was 12.2% (n=63/515). Being a non-citizen was associated with significantly higher seroprevalence (OR 2.10, p=0.02). Participants with history of SARS-CoV-2 exposure or symptoms regardless of SARS-CoV-2 diagnosis had higher SARS-CoV-2 IgG positivity compared to unexposed or asymptomatic participants (OR 2.47, p=0.0008 or 11.19, p=0.0001, respectively). Blood donors who had symptomatic SARS-CoV-2 IgG infection had a higher SARS-CoV-2 IgG positivity rate (OR 5.04, p=0.008) and index value (p=0.003) than the asymptomatic. Of all the reported symptoms, cough (p=0.004) and anosmia (p=0.002) were significant predictors of SARS-CoV-2 IgG.Conclusion: The seroprevalence of SARS-CoV-2 among the blood donors in Riyadh, Saudi Arabia is considerably lower than the percentages necessary for herd immunity. Developing SARS-CoV-2-symptoms is the critical factor for higher seropositivity after SARS-CoV-2 exposure.