PT  - JOURNAL ARTICLE
AU  - Al Sheikh, Khalid
AU  - AlHandi, Ali
AU  - Bin Dohaim, Abrar
AU  - Ateeq, Khawlah
AU  - AlAqeely, Khalid
TI  - Effectiveness of using tranexamic acid in total hip and total knee arthroplasty
AID  - 10.15537/smj.2021.42.8.20210332
DP  - 2021 Aug 01
TA  - Saudi Medical Journal
PG  - 908--912
VI  - 42
IP  - 8
4099  - http://smj.org.sa/content/42/8/908.short
4100  - http://smj.org.sa/content/42/8/908.full
SO  - Saudi Med J2021 Aug 01; 42
AB  - Objectives: To measure the effectiveness of tranexamic acid (TXA); in total joint arthroplastyin terms of reducing post-operative blood loss.Methods: A retrospective cohort study in which patients who had underwent total hip arthroplasty (THA) and TKA between 2010-2018 in a single tertiary center. Those had received TXA (group 1) and those who had received no-TXA (group 2) were evaluated. Unpaired student’s t-test was used to compare TXA and no-TXA groups for continuous variables and Chi-square test was used for categorical variables. A p-value<0.05 was considered significant.Results: A total of 385 patients were included, 180 patients received TXA, and 205 patients received no-TXA. Post-operative blood loss was significantly less in TXA group (13.41±9.51, p<0.001). Total drainage output was significantly lower in TXA group compared to no-TXA (373.98±246.12 vs. 487.11±307.13 mL, p<0.001). Blood transfusion units were significantly less in TXA group than in the control group (20 units; 11.1% vs. 50 units; 24.4%, p<0.001).Conclusion: Tranexamic acid use in TKA and THA is effective in reducing post-operative blood loss in terms of drop in Hg level, total drainage output and blood transfusion rate.