RT Journal Article
SR Electronic
T1 Utility of ferritin and inflammatory biomarkers in the diagnosis of different stages of breast cancer
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 825
OP 831
DO 10.15537/smj.2021.42.8.20210244
VO 42
IS 8
A1 George, Anila
A1 Bobby, Zachariah
A1 Dubashi, Biswajit
YR 2021
UL http://smj.org.sa/content/42/8/825.abstract
AB Objectives: To assess the utility of ferritin and inflammatory biomarkers in the diagnosis of stages of breast cancer.Methods: The study consisted of 4 groups of 20 women, including the healthy control. The patients of group 1 comprised of stages I and II, group 2: stage III and group 3: stage IV of the disease. High sensitive C-reactive protein (hsCRP) and hepcidin were estimated by enzyme linked immunosorbent assay and ferritin by chemiluminescence immunoassay. The study was carried out in 2018 at Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry-6, India.Results: The breast cancer disease progression correlated negatively with hemoglobin (Hb) (r= -0.6937, p<0.0001) and with ferritin levels, had a positive correlation (r=0.8444, p<0.0001). Ferritin negatively correlated with Hb among the subjects of the study (r= -0.6130, p<0.0001). Hepcidin correlated positively with hsCRP (r=0.998, p<0.0001). The ferritin/Hb ratio >3.9516 was used to identify the possibility of breast cancer utilizing the receiver operator curve values (area under curve [AUC]=0.997, sensitivity: 96.7, specificity:100). Ferritin values >103.4 were used to differentiate stage 4 from stage 3 of the disease (AUC: 0.893, sensitivity: 100, specificity: 85).Conclusion: Ferritin and ferritin/Hb are helpful in the differential diagnosis of stages of breast cancer.