RT Journal Article SR Electronic T1 Woodhouse-Sakati syndrome (WSS) JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1237 OP 1242 DO 10.15537/smj.2021.42.11.20210329 VO 42 IS 11 A1 Mariam S. Alharbi YR 2021 UL http://smj.org.sa/content/42/11/1237.abstract AB Woodhouse-Sakati syndrome (WSS) is a rare genetic condition of autosomal recessive inheritance pattern. The disease is characterized by a group of disorders, including diabetes mellitus, alopecia, hypogonadism, intellectual disability, and progressive extrapyramidal signs. This syndrome is related to an inherited neurodegenerative disorder’s heterogeneous group characterized by the accumulation of iron in the brain, caused by a mutation in the DCAF17 gene. This report discusses the case of 3 Saudi sisters having WWS. The 3 sisters aged 18, 22, and 25 years took birth to consanguineous parents (first-degree cousins). The sisters initially had normal developmental growth with deprived scholastic performance because of the intellectual difficulties. At puberty, the secondary sexual characteristics were not developed in the patients, and they faced primary amenorrhea. They were found to have features typical of WSS, but they also had gynecological anomalies, which are considered unusual findings in WSS patients.