RT Journal Article SR Electronic T1 Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 132 OP 138 DO 10.15537/smj.2022.43.2.20210822 VO 43 IS 2 A1 Amjad M. Yousuf A1 Firoz A. Kannu A1 Talha M. Youssouf A1 Fatimah N. Alsuhaimi A1 Abdulaziz M. Aljohani A1 Fayez H. Alsehli A1 Omar F. Khabour A1 Yahya A. Almutawif A1 Mustafa A. Najim A1 Hatem A. Mahmood YR 2022 UL http://smj.org.sa/content/43/2/132.abstract AB Objectives: To study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters.Methods: This study was carried out on 118 diabetic patients and 106 healthy individuals (control) from Prince Mohammed bin Abdulaziz Hospital, Al Madinah Al Munawarah, Saudi Arabia. The TaqMan single-nucleotide polymorphism (SNP)genotyping assay was used for rs8050136 genotyping.Results: The frequency of the genotype AA was the same among T2DM and healthy control groups (21%). However, the frequency of genotype CC was 19.5% in T2DM patients and 24.5% in control individuals. There was no significant association between FTO SNP rs8050136 and an increased risk of T2DM. Furthermore, there was no association between the risk AA genotype and fasting blood glucose (p=0.092), glycated hemoglobin (p=0.177), or body mass index (p=0.561).Conclusion: Our findings show that the FTO rs8050136 A>C variant is not associated with T2DM in the Saudi population.