TY - JOUR T1 - The effect of low flow anesthesia with sevoflurane on oxidative status JF - Saudi Medical Journal JO - Saudi Med J SP - 227 LP - 235 DO - 10.15537/smj.2022.43.3.20210876 VL - 43 IS - 3 AU - Hülya Kaşıkara AU - Ayça T. Dumanlı Özcan AU - Cemile K. Biçer AU - Almila Şenat AU - Abdüssamet Yalçın AU - Cemile Altın AU - Şemsi Mustafa Aksoy AU - Abdülkadir But Y1 - 2022/03/01 UR - http://smj.org.sa/content/43/3/227.abstract N2 - Objectives: To assess the impact of low-flow, mid-flow, and high-flow sevoflurane anesthesia on the oxidative state by measuring thiol/disulfide levels in patients undergoing surgery.Methods: The study included 99 patients randomly assigned to 3 groups. In the low-flow anesthesia group, the fresh gas flow was diminished to 1 L.min-1 for anesthesia maintenance after 6 L.min-1 was administered for the first 10 minutes. In the mid-flow anesthesia group, fresh gas flow was applied as 2 L.min-1. In the high-flow anesthesia group, the fresh gas flow was administered as 4 L.min-1 throughout the operation. Blood samples were obtained before induction, at the 60th minute after induction, and at 2 hours postoperatively. Native thiol, total thiol, disulfide analyzed and disulfide/native thiol percentage, disulfide/total thiol percentage, and native thiol/total thiol percentage were calculated.Results: Disulfide values in mid-flow and low-flow anesthesia were significantly lower at the 60th minute after induction compared to the high-flow anesthesia group. In the group evaluations, intraoperative native thiol levels in the high-flow group were found to be substantialy lower than preoperative values.Conclusion: It was sighted that low-flow anesthesia with sevoflurane prohibited oxidative damage. It was concluded that low flow anesthesia can be utilized safely in this respect. ER -