RT Journal Article
SR Electronic
T1 Impact on the survival of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, and monocyte-lymphocyte ratio on prognosis in children with Hodgkin lymphoma
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 451
OP 457
DO 10.15537/smj.2022.43.5.20210916
VO 43
IS 5
A1 Ertan, Kubra
A1 Dogru, Aysenur
A1 Kara, Buket
A1 Koksal, Yavuz
YR 2022
UL http://smj.org.sa/content/43/5/451.abstract
AB Objectives: To evaluate the clinical utility of the recently described absolute neutrophil counts to absolute lymphocyte counts ratio (NLR), absolute platelet counts to absolute lymphocyte counts ratio (PLR), and absolute monocyte counts to absolute lymphocyte counts ratio (MLR) on prognosis in children with Hodgkin lymphoma (HL).Methods: We retrospectively evaluated the clinical characteristics, laboratory features (lymphocyte counts, NLR, PLR, and MLR), treatment, and results of 52 children with HL in the Department of Pediatric Hematology and Oncology, Selcuk University, konya, Turkey, from January 2006 until December 2021.Results: The patients included 27 (51.9%) females and 25 (48.1%) males. The age of the patients ranged between 3-17.5 years old (median: 9 years). There were 22 patients in stage II, 24 in stage III, and 6 in stage IV. The most prevalent histopathological subgroup was the nodular sclerosing type (53.8%). The 5-year overall survival rate was 93.7%. The overall survival rate differed based on lymphocyte counts (p<0.0001), NLR (p=0.018), and PLR (p=0.009). However, none of the prognostic factors in the univariate analysis were not prognostic risk factors (p>0.05) in the multivariate analysis.Conclusion: Lymphocyte counts, NLR, and PLR may be useful markers for determining the outcomes in children with HL.