RT Journal Article SR Electronic T1 Clinical and ultrasonographic features in cancer risk stratification of indeterminate thyroid nodules JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 473 OP 478 DO 10.15537/smj.2022.43.5.20220045 VO 43 IS 5 A1 Saad M. Alqahtani A1 Sultan F. Alanesi A1 Waqas S. Mahmood A1 Yassin M. Moustafa A1 Laila M. Moharram A1 Nawaf F. Alharthi A1 Attiya M. Alzahrani A1 Yousef S. Alalawi YR 2022 UL http://smj.org.sa/content/43/5/473.abstract AB Objectives: To estimate the risk of malignancy in indeterminate thyroid nodules and to determine whether certain clinical or radiological parameters can predict the risk of malignancy.Methods: This retrospective study enrolled all adult patients (age ≥14 years) with a cytological diagnosis of atypia/follicular lesion of undetermined significance and follicular neoplasm/suspicious for a follicular neoplasm between January 2014 and January 2020. Fifty patients with surgically treated primary thyroid nodules, documented final histological diagnosis, and ultrasound examination records were included. Thyroid nodules were evaluated radiologically using Thyroid Imaging Reporting and Data System introduced by the American College of Radiology (2017).Results: Forty-two (84.0%) female and 8 (16.0%) male patients were enrolled in the study. The malignancy risks were 44.8% for Bethesda III and 28.6% for Bethesda IV. The malignancy risks for the Thyroid Imaging Reporting and Data System categories were 33.3% (TR2), 39.1% (TR3), 35.3% (TR4), and 50% (TR5). No significant associations were observed between age, gender, Bethesda category, and Thyroid Imaging Reporting and Data System and the risk of malignancy.Conclusion: None of the clinical or radiological characteristics evaluated in this study contributed to the cancer risk stratification of thyroid nodules with indeterminate cytology. A prospective multicenter study is needed to better understand cytologically indeterminate thyroid nodules.