PT  - JOURNAL ARTICLE
AU  - Aamir Waheed, Muhammad
AU  - Rashid, Khalid
AU  - Rajab, Tawfik
AU  - Rajab, Ahmad
AU  - Adnan, Adnan H.
AU  - Fayyaz, Harris
AU  - Ibad, Ahmad A.
AU  - Basri, Rabia
AU  - Khan, Yahya
AU  - Alhabib, Habib I.
AU  - Elzouki, Abdelnaser
TI  - Role of anticoagulation in lowering the mortality in hospitalized covid-19 patients
AID  - 10.15537/smj.2022.43.6.20220046
DP  - 2022 Jun 01
TA  - Saudi Medical Journal
PG  - 541--550
VI  - 43
IP  - 6
4099  - http://smj.org.sa/content/43/6/541.short
4100  - http://smj.org.sa/content/43/6/541.full
SO  - Saudi Med J2022 Jun 01; 43
AB  - Objectives: To reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitted with covid-19.Methods: A total of 7120 patients were recruited in 11 studies comparing using prophylactic anticoagulants against therapeutic anticoagulants.Results: Our study showed that using prophylactic anticoagulants was associated with a 42% reduction in mortality compared to therapeutic anticoagulants (OR 0.58 (95% CI:0.676-0.499), p=0.000). Also, we assessed mortality in patients using no anticoagulants against using prophylactic anticoagulants. A total of 6069 patients were recruited in 4 studies in which 2 studies significantly favored prophylactic anticoagulants in terms of reducing mortality. Cumulatively, the meta-analysis showed that using prophylactic anticoagulants was associated with a 5% reduction in mortality but without any statistical significance: (OR 1.049 [95% CI 1.237 - 0.865]) (p=0.626).Conclusion: Our meta-analysis favors using prophylactic anticoagulation in covid-19 patients reduces all-cause mortality in comparison to therapeutic anticoagulation however the impact on mortality when compared with no anticoagulation was not significant.PROSPERO Number: CRD42021257320