RT Journal Article SR Electronic T1 Role of anticoagulation in lowering the mortality in hospitalized covid-19 patients JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 541 OP 550 DO 10.15537/smj.2022.43.6.20220046 VO 43 IS 6 A1 Muhammad Aamir Waheed A1 Khalid Rashid A1 Tawfik Rajab A1 Ahmad Rajab A1 Adnan H. Adnan A1 Harris Fayyaz A1 Ahmad A. Ibad A1 Rabia Basri A1 Yahya Khan A1 Habib I. Alhabib A1 Abdelnaser Elzouki YR 2022 UL http://smj.org.sa/content/43/6/541.abstract AB Objectives: To reducing the risk of venous thromboembolic (VTE) events and subsequent mortality in covid-19 patients is still a matter of research. This systematic review and meta-analysis serve the purpose of comparing the mortality associated with the intensity of anticoagulation in patients admitted with covid-19.Methods: A total of 7120 patients were recruited in 11 studies comparing using prophylactic anticoagulants against therapeutic anticoagulants.Results: Our study showed that using prophylactic anticoagulants was associated with a 42% reduction in mortality compared to therapeutic anticoagulants (OR 0.58 (95% CI:0.676-0.499), p=0.000). Also, we assessed mortality in patients using no anticoagulants against using prophylactic anticoagulants. A total of 6069 patients were recruited in 4 studies in which 2 studies significantly favored prophylactic anticoagulants in terms of reducing mortality. Cumulatively, the meta-analysis showed that using prophylactic anticoagulants was associated with a 5% reduction in mortality but without any statistical significance: (OR 1.049 [95% CI 1.237 - 0.865]) (p=0.626).Conclusion: Our meta-analysis favors using prophylactic anticoagulation in covid-19 patients reduces all-cause mortality in comparison to therapeutic anticoagulation however the impact on mortality when compared with no anticoagulation was not significant.PROSPERO Number: CRD42021257320