PT  - JOURNAL ARTICLE
AU  - Aljohani, Somaya A.
AU  - Saib, Israa H.
AU  - Syed, Ghulam Shah
AU  - Alruwaili, Ahmed
AU  - Numani, Shah P.
AU  - Almuthri, Sulaiman A.
AU  - Vishwakarm, Ramesh K.
AU  - Mendoza, May Anne C.
AU  - Alsalman, Mohammed J.
AU  - Ozair, Nabil M.
AU  - Alhejazi, Ayman Y.
AU  - Alaskar, Ahmed S.
AU  - Gmati, Giamal E.
TI  - Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy
AID  - 10.15537/smj.2022.43.8.20220055
DP  - 2022 Aug 01
TA  - Saudi Medical Journal
PG  - 959--964
VI  - 43
IP  - 8
4099  - http://smj.org.sa/content/43/8/959.short
4100  - http://smj.org.sa/content/43/8/959.full
SO  - Saudi Med J2022 Aug 01; 43
AB  - Objectives: To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.Methods: A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included.Results: The high sensitivity and specificity of positron emission tomography/computed tomography (PET/CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment.Conclusion: Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion.