PT  - JOURNAL ARTICLE
AU  - Somaya A. Aljohani
AU  - Israa H. Saib
AU  - Ghulam Shah Syed
AU  - Ahmed Alruwaili
AU  - Shah P. Numani
AU  - Sulaiman A. Almuthri
AU  - Ramesh K. Vishwakarm
AU  - May Anne C. Mendoza
AU  - Mohammed J. Alsalman
AU  - Nabil M. Ozair
AU  - Ayman Y. Alhejazi
AU  - Ahmed S. Alaskar
AU  - Giamal E. Gmati
TI  - Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy
AID  - 10.15537/smj.2022.43.8.20220055
DP  - 2022 Aug 01
TA  - Saudi Medical Journal
PG  - 959--964
VI  - 43
IP  - 8
4099  - http://smj.org.sa/content/43/8/959.short
4100  - http://smj.org.sa/content/43/8/959.full
SO  - Saudi Med J2022 Aug 01; 43
AB  - Objectives: To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.Methods: A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included.Results: The high sensitivity and specificity of positron emission tomography/computed tomography (PET/CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment.Conclusion: Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion.