RT Journal Article
SR Electronic
T1 Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 959
OP 964
DO 10.15537/smj.2022.43.8.20220055
VO 43
IS 8
A1 Aljohani, Somaya A.
A1 Saib, Israa H.
A1 Syed, Ghulam Shah
A1 Alruwaili, Ahmed
A1 Numani, Shah P.
A1 Almuthri, Sulaiman A.
A1 Vishwakarm, Ramesh K.
A1 Mendoza, May Anne C.
A1 Alsalman, Mohammed J.
A1 Ozair, Nabil M.
A1 Alhejazi, Ayman Y.
A1 Alaskar, Ahmed S.
A1 Gmati, Giamal E.
YR 2022
UL http://smj.org.sa/content/43/8/959.abstract
AB Objectives: To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.Methods: A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included.Results: The high sensitivity and specificity of positron emission tomography/computed tomography (PET/CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment.Conclusion: Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion.