TY - JOUR T1 - Radiological outcome of bone disease in multiple myeloma patients pre- and post therapy JF - Saudi Medical Journal JO - Saudi Med J SP - 959 LP - 964 DO - 10.15537/smj.2022.43.8.20220055 VL - 43 IS - 8 AU - Somaya A. Aljohani AU - Israa H. Saib AU - Ghulam Shah Syed AU - Ahmed Alruwaili AU - Shah P. Numani AU - Sulaiman A. Almuthri AU - Ramesh K. Vishwakarm AU - May Anne C. Mendoza AU - Mohammed J. Alsalman AU - Nabil M. Ozair AU - Ayman Y. Alhejazi AU - Ahmed S. Alaskar AU - Giamal E. Gmati Y1 - 2022/08/01 UR - http://smj.org.sa/content/43/8/959.abstract N2 - Objectives: To find any correlation between the clinical response as per International Working Myeloma Group (IWMG) response criteria and the radiological response at the end of treatment.Methods: A retrospective cohort study was conducted, total of 39 patients whom diagnosed with multiple myeloma (MM) between January 2010 and December 2018 and fulfilled the study criteria were included.Results: The high sensitivity and specificity of positron emission tomography/computed tomography (PET/CT) in detecting osteolytic myeloma lesions in the bones was strongly emphasized in our study. Follow up PET/CT, we found that while 17 patients showed complete remission in PET/CT, and 14 of these of patients demonstrated a complete clinical response at end of therapy assessment.Conclusion: Although we did not find a statistically significant correlation between the response versus metabolic activity and the number of bone/bone marrow lesions, however, our study was limited by the absence of clear criteria for defining disease response in PET/CT in MM patients. Further prospective analysis would be needed to establish a defined criterion. ER -