TY - JOUR T1 - Seroprevalence of community-acquired atypical bacterial pneumonia among adult COVID-19 patients from a single center in Al Madinah Al Munawarah, Saudi Arabia JF - Saudi Medical Journal JO - Saudi Med J SP - 1000 LP - 1006 DO - 10.15537/smj.2022.43.9.20220379 VL - 43 IS - 9 AU - Sari T. Alhoufie AU - Nadir A. Ibrahim AU - Naif H. Alsharif AU - Khalid O. Alfarouk AU - Hatim M. Makhdoom AU - Khaled R. Aljabri AU - Sayed H. Saeed AU - Adnan A. Khoumaeys AU - Yahya A. Almutawif AU - Mustafa A. Najim AU - Hamza M. Ali AU - Alanoud A. Aljifri AU - Ali M. Kheyami AU - Areej A. Alhazmi Y1 - 2022/09/01 UR - http://smj.org.sa/content/43/9/1000.abstract N2 - Objectives: To investigate the seroprevalence of the community-acquired bacterial that causes atypical pneumonia among confirmed severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) patients.Methods: In this cohort study, we retrospectively investigated the seroprevalence of Chlamydia pneumoniae, Mycoplasma pneumoniae, and Legionella pneumophila among randomly selected 189 confirmed COVID-19 patients at their time of hospital presentation via commercial immunoglobulin M (IgM) antibodies against these bacteria. We also carried out quantitative measurements of procalcitonin in patients’ serum.Results: The seropositivity for L. pneumophila was 12.6%, with significant distribution among patientsolder than 50 years (χ2 test, p=0.009), while those of M. pneumoniae was 6.3% and C. pneumoniae was 2.1%, indicating an overall co-infection rate of 21% among COVID-19 patients. No significant difference (χ2 test, p=0.628) in the distribution of bacterial co-infections existed between male and female patients. Procalcitonin positivity was confirmed amongst 5% of co-infected patients.Conclusion: Our study documented the seroprevalence of community-acquired bacteria co-infection among COVID-19 patients. In this study, procalcitonin was an inconclusive biomarker for non-severe bacterial co-infections among COVID-19 patients. Consideration and proper detection of community-acquired bacterial co-infection may minimize misdiagnosis during the current pandemic and positively reflect disease management and prognosis. ER -