PT - JOURNAL ARTICLE AU - AlFaris, Huda AU - Alkathiri, Sarah A. AU - Babelli, Doha AU - Alokaily, Fahdah TI - Double malignancy and a mycobacterial infection in a rheumatoid arthritis patient AID - 10.15537/smj.2022.43.9.20220563 DP - 2022 Sep 01 TA - Saudi Medical Journal PG - 1062--1065 VI - 43 IP - 9 4099 - http://smj.org.sa/content/43/9/1062.short 4100 - http://smj.org.sa/content/43/9/1062.full SO - Saudi Med J2022 Sep 01; 43 AB - Rheumatoid arthritis is a common autoimmune disease. Malignancy is a serious complication of rheumatoid arthritis and its treatment. In this article, we discuss a 61-year-old woman who is a known case of Rheumatoid arthritis and secondary Sjögren’s syndrome treated with disease-modifying anti-rheumatoid drugs and multiple lines of biological therapies. She was found to have recto-sigmoid cancer, disseminated tuberculosis infection, and acute lymphoid leukemia at different intervals of treatment. Therefore, it is advisable to initiate appropriate screening programs that target high-risk people for malignancy.