@article {Zhao1217, author = {Ping Zhao and Liang Chen and Ze Q. Xie and Ji Y. Jian and Pan P. Sun}, title = {Clinical significance of CA-125 in elderly patients with active pulmonary tuberculosis}, volume = {43}, number = {11}, pages = {1217--1223}, year = {2022}, doi = {10.15537/smj.2022.43.11.20220460}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To assess the clinical significance of serum CA-125 levels in elderly patients with pulmonary tuberculosis (PTB).Methods: We retrospectively analyzed 1613 participants{\textendash}patients (aged >=60 years) admitted to the Beijing Shijitan Hospital, Beijing, China from February 2015 to January 2021 and healthy participants, divided into 4 groups: PTB (group 1), pulmonary malignancies (group 2), pulmonary non-malignant diseases (group 3), and healthy participants (group 4). Data concerning demographics, physical examination findings, computed tomography, histopathological examination, and laboratory tests for Mycobacterium tuberculosis and serum CA-125 levels were collected and analyzed.Results: There were 720 healthy individuals and 893 patients in the study. The median levels and abnormal rates of CA-125 in groups 1 (42.5, 57.3\%) and 2 (34.4, 49.5\%) were higher than those in groups 3 (21.1, 29.2\%) and 4 (8.6, 0.4\%) (p\<0.05). The ordinal logistic regression analysis model revealed significant associations between CA-125 levels and PTB (OR and 95\% confidence interval [CI]: 2.749 (1.876-4.027)), hypoproteinemia [OR and 95\% CI: 1.519 (1.114-2.070)], serous effusion [OR and 95\% CI: 7.364 (5.346-10.143)], pulmonary malignancy [OR and 95\% CI: 2.206 (1.518-3.204)], respiratory failure [OR and 95\% CI: 3.216 (2.087-4.956)], and cor pulmonale [OR and 95\% CI: 2.990 (1.282-6.973)].Conclusion: Although elevated CA-125 levels may serve as a potential marker for diagnosing PTB in the elderly, they are affected by multiple factors, including serous effusion. Hence, caution is warranted while using this marker.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/43/11/1217}, eprint = {https://smj.org.sa/content/43/11/1217.full.pdf}, journal = {Saudi Medical Journal} }