RT Journal Article SR Electronic T1 Evaluate the side effect associated with COVID-19 vaccine on adolescents in Riyadh, Saudi Arabia JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 1248 OP 1253 DO 10.15537/smj.2022.43.11.20220493 VO 43 IS 11 A1 Jehad A. Aldali A1 Fahad T. Alotaibi A1 Glowi A. Alasiri A1 Renad A. Almesned A1 Aroob M. Alromih A1 Afnan M. Almohandes A1 Shahad F. Alsenidi YR 2022 UL http://smj.org.sa/content/43/11/1248.abstract AB Objectives: To investigate the side effects of Pizer- BioNTech mRNA (BNT162b2) and Spikevax (mRNA- 1273) Coronavirus disease 2019 (COVID-19) vaccines on adolescents in Riyadh, Saudi Arabia.Methods: A cross-sectional study using an online questionnaire was carried out among COVID-19 vaccine adolescent recipients in Riyadh, Saudi Arabia. After receiving at least one dose of each vaccine, general and demographic data were collected, and vaccine-related side effects were evaluated.Results: The final sample consisted of 604 participants with a majority age group of 16-17 years old. Approximately 89.1% of the study participants were female. Most participants reported pain at the injection site (85.1% 1st dose, 79.8% 2nd dose), feeling tired, and headache (58.6% 1st dose, 64.2% 2nd dose). Moreover, we found that patients who took the first dose and had a chronic disease had 2.4 times higher odds of having menstrual disorder (females) than non-chronic disease patients (p=0.03) and 4.5 times higher odds of exhibiting breathing congestion (p=0.01). In addition, patients with chronic disease had 2.4 times higher odds of exhibiting muscle and joint pain and dizziness than non-chronic disease patients (p=0.01, p=0.02). Males were less likely to have dizziness after the first dose than females (OR=0.26, p=0.01).Conclusion: This study investigates the adverse effects of COVID-19 vaccines among adolescents in Riyadh. As a result, this study creates a database to inform people about the risk of experiencing side effects based on their gender, age, and the vaccine type; more investigation is needed to better understand the link between risk factors and the development of adverse effects.