PT  - JOURNAL ARTICLE
AU  - Alsughayyir, Jawaher
AU  - Almalki, Yasser
AU  - Alburayk, Imtinan
AU  - Alalshaik, Mohrah
AU  - Aljoni, Ibrahim
AU  - Kandel, Mona
AU  - Alfhili, Mohammad A.
AU  - Alabdullateef, Abdulmajeed A.
TI  - Prevalence of transfusion-transmitted infections in Saudi Arabia blood donors
AID  - 10.15537/smj.2022.43.12.20220634
DP  - 2022 Dec 01
TA  - Saudi Medical Journal
PG  - 1363--1372
VI  - 43
IP  - 12
4099  - http://smj.org.sa/content/43/12/1363.short
4100  - http://smj.org.sa/content/43/12/1363.full
SO  - Saudi Med J2022 Dec 01; 43
AB  - Objectives: To establish a nationwide epidemiological profile of transfusion-transmittable infection (TTI) markers among seemingly healthy blood donors to update policies required to ensure blood safety.Methods: A nationwide, cross-sectional study was designed to examine donor demographics and TTI prevalence during 2020 using data provided by the Ministry of Health, Saudi Arabia.Results: Collectively, a total of 375,218 whole blood units were donated, of which 32,758 (8.7%) were excluded due to TTI-related risk. The exclusion was based on a positive nucleic acid amplification test (NAT) or seroreactivity to hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), human T-cell lymphotropic virus (HTLV-I/II), syphilis, or malaria. Notably, the central (37.6%) and southern (33%) regions were the epicenters of TTI-reactive blood donors. Hepatitis B virus markers accounted for 85.7% and were the overall most prevalent of TTI-positive donations, followed by HCV at 5.9% and syphilis at 5.6%. In particular, anti-HBc and HBsAg were most prevalent in the south, while HBV NAT was highest in the center.Conclusion: Hepatitis B virus, HCV, and syphilis carry the greatest risk of TTI in Saudi Arabia. Including HBsAg screening is a necessary precautious measure to maintain blood safety.