TY - JOUR T1 - Does the preoperative fasting period affect the liver in a distant organ model of renal ischaemia reperfusion? JF - Saudi Medical Journal JO - Saudi Med J SP - 171 LP - 177 DO - 10.15537/smj.2023.44.2.20220582 VL - 44 IS - 2 AU - Yasemin Akcaalan AU - Ersin Gurkan Dumlu AU - Ebru Menekse AU - Mustafa Cem Yilmaz AU - Ezgi Erkilic AU - Betul Ogut AU - Aylin Sepıcı Dıncel Y1 - 2023/02/01 UR - http://smj.org.sa/content/44/2/171.abstract N2 - Objectives: To experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury.Methods: This is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-α), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically.Results: A statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (p=0.020) with significantly lower levels determined in Group C than in Groups A and B (p=0.021). Similar rates of mild nuclear polymorphism were seen with no statistically significant difference determined between the groups (p>0.167). A statistically significant difference was determined between the groups in respect of the congestion scores (p<0.001), with a lower score in Group C than in Groups A and B, where the scores were similar (p<0.001, p=0.017).Conclusion: With this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue. ER -