RT Journal Article
SR Electronic
T1 Does the preoperative fasting period affect the liver in a distant organ model of renal ischaemia reperfusion?
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 171
OP 177
DO 10.15537/smj.2023.44.2.20220582
VO 44
IS 2
A1 Akcaalan, Yasemin
A1 Dumlu, Ersin Gurkan
A1 Menekse, Ebru
A1 Yilmaz, Mustafa Cem
A1 Erkilic, Ezgi
A1 Ogut, Betul
A1 Dıncel, Aylin Sepıcı
YR 2023
UL http://smj.org.sa/content/44/2/171.abstract
AB Objectives: To experimentally evaluate the effects of preoperative fasting duration on distant organ liver in renal ischaemia-reperfusion (IR) injury.Methods: This is an experimental study. In the study, 3 groups were formed. In Group A, abdominal laparotomy was carried out after 12 hours of preoperative fasting without any IR damage. In Group B, IR injury was carried out after 12 hours of preoperative fasting, and abdominal laparotomy was carried out, in Group C after 2 hours of fasting after IR injury. Apoptosis, congestion, balloon degeneration, nuclear pleomorphism, and leukocyte infiltration were examined histopathologically and tumor necrosis factor-alpha (TNF-α), interleukin (IL) -1 beta, IL-6, and IL-10 were evaluated biochemically.Results: A statistically significant difference was determined between the groups in respect of postoperative IL-10 levels (p=0.020) with significantly lower levels determined in Group C than in Groups A and B (p=0.021). Similar rates of mild nuclear polymorphism were seen with no statistically significant difference determined between the groups (p>0.167). A statistically significant difference was determined between the groups in respect of the congestion scores (p<0.001), with a lower score in Group C than in Groups A and B, where the scores were similar (p<0.001, p=0.017).Conclusion: With this result, it would be correct to say that the short preoperative fasting period has protective effects on the liver tissue.