@article {Alradadi284, author = {Rasha S. Alradadi and Noura A. Omar and Renad A. Alhusayni and Amirah M. Almokhtar and Shahad F. Muhawish and Mawaddah M. Altaleb and Sundus A. Tawfiq and Reem M. Alraddadi and Randa Q. Almalki}, title = {The characteristics of Grave{\textquoteright}s disease in children and adolescent patients in Al-Madinah Al-Munawwarah}, volume = {44}, number = {3}, pages = {284--288}, year = {2023}, doi = {10.15537/smj.2023.44.3.20220501}, publisher = {Saudi Medical Journal}, abstract = {Objectives: To determine the characteristics of Graves{\textquoteright} disease in children and adolescents in Medina, the Kingdom of Saudi Arabia, and compare them to those observed in other countries.Methods: This is a retrospective chart review of children and adolescents diagnosed with Graves{\textquoteright} disease between January 2010 and May 2021.Results: Fifty-eight patients aged 12.02 {\textpm} 4.85 years were identified, of which 44 (75.9\%) were females. Exophthalmos (63.8\%), neck swelling (60.3\%), palpitations (46.6\%), and tremors (29.3\%) were the most common manifestations. Vitiligo (1.72\%) and alopecia (1.72\%) were the only autoimmune diseases observed in our patients. The median (IQR) value was 0.01 (0.36) (ulU/mL) for thyroid-stimulating hormone (TSH) and 24.89 (29.50) (pmol/L) for FT4. In terms of treatment modalities, 55 (94.8\%) received antithyroid medication, 6 (10.3\%) underwent thyroidectomy and one patient (1.72\%) was treated with radioactive iodine.Conclusion: In general, Graves{\textquoteright} disease is more common in females. Neck swelling, palpitation, and tremors were the main manifestations. Compared with other countries, there was a higher frequency of exophthalmos and a lower frequency of associated autoimmune conditions. The primary treatment was antithyroid drugs; thyroidectomy and radioactive iodine were used less frequently.}, issn = {0379-5284}, URL = {https://smj.org.sa/content/44/3/284}, eprint = {https://smj.org.sa/content/44/3/284.full.pdf}, journal = {Saudi Medical Journal} }