RT Journal Article
SR Electronic
T1 The characteristics of Grave’s disease in children and adolescent patients in Al-Madinah Al-Munawwarah
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 284
OP 288
DO 10.15537/smj.2023.44.3.20220501
VO 44
IS 3
A1 Rasha S. Alradadi
A1 Noura A. Omar
A1 Renad A. Alhusayni
A1 Amirah M. Almokhtar
A1 Shahad F. Muhawish
A1 Mawaddah M. Altaleb
A1 Sundus A. Tawfiq
A1 Reem M. Alraddadi
A1 Randa Q. Almalki
YR 2023
UL http://smj.org.sa/content/44/3/284.abstract
AB Objectives: To determine the characteristics of Graves’ disease in children and adolescents in Medina, the Kingdom of Saudi Arabia, and compare them to those observed in other countries.Methods: This is a retrospective chart review of children and adolescents diagnosed with Graves’ disease between January 2010 and May 2021.Results: Fifty-eight patients aged 12.02 ± 4.85 years were identified, of which 44 (75.9%) were females. Exophthalmos (63.8%), neck swelling (60.3%), palpitations (46.6%), and tremors (29.3%) were the most common manifestations. Vitiligo (1.72%) and alopecia (1.72%) were the only autoimmune diseases observed in our patients. The median (IQR) value was 0.01 (0.36) (ulU/mL) for thyroid-stimulating hormone (TSH) and 24.89 (29.50) (pmol/L) for FT4. In terms of treatment modalities, 55 (94.8%) received antithyroid medication, 6 (10.3%) underwent thyroidectomy and one patient (1.72%) was treated with radioactive iodine.Conclusion: In general, Graves’ disease is more common in females. Neck swelling, palpitation, and tremors were the main manifestations. Compared with other countries, there was a higher frequency of exophthalmos and a lower frequency of associated autoimmune conditions. The primary treatment was antithyroid drugs; thyroidectomy and radioactive iodine were used less frequently.